OBJECTIVES

Our lab uses a wide variety of experimental approaches to understand how sensory, limbic and motor brain circuits in mammals adjust to drug abuse, in particular psychostimulant drugs. We do this by integrating well-established behavioral models, with molecular and biochemical techniques and electrophysiological recordings.  In the last few years, we have described various thalamocortical alterations induced by addictive (cocaine) and non-addictive (methylphenidate) psychostimulants. In addition, we have showed profound changes in areas of the meso-cortico-limbic system induced by other highly addictive psychostimulant (methamphetamine) in mice.  We have also described neuroprotective properties of another psychostimulant, modafinil , against methamphetamine striatal toxicity. We are currently investigating how addictive and non-addictive psychostimulants change epigenetic regulators within CNS.

MEMBERS

Principal Investigator

VERÓNICA BISAGNO

Vice-Director Pharmacological Research Institute – ININFA – UBA-CONICET.

Independent Researcher, Researcher Carreer, CONICET.

Assistant Researcher

BETINA GONZALEZ

Lic. en Ciencias Biológicas, FCEyN, UBA. PhD at Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales. RESEARCH AREA: PHARMACOLOGY

Assistant Researcher, Researcher Carreer, CONICET. Director: Dra. Verónica Bisagno. Co-Director: Dr. Francisco J. Urbano

Postdoctoral fellow

MARIA ALEJANDRA BERNARDI

PhD., Postdoctoral Fellow, ANPCyT. Director: Dra. Veronica Bisagno.

Students

JAVIER ANDRÉS MUÑIZ

Lic. en Biotecnología. PhD Candidate, University of Buenos Aires. RESEARCH AREA: PHARMACOLOGY.

MARIA CELESTE SOLANGE, RIVERO-ECHETO

Medica, FCEyN, UBA. PhD Candidate, University of Buenos Aires. AREA DE INVESTIGACIÓN: NEUROCIENCIA.

JOSÉ PEDRO PRIETO

Magister, Instituto de Investigaciones Clemente Estable, Montevideo. PhD Candidate, IIBCE, Montevideo, Uruguay

PUBLICATIONS

https://www.researchgate.net/profile/Veronica_Bisagno

FUNDING

CONICET, PIP 11420100100072, Argentina. (Bisagno, – PI) Protective role of modafinil against methamphetamine toxicity in mice. 2011 – 2013 Total $Ars 36.000, USD$ 5500.

ANPCyT, FONCYT, PICT 2007-1009, Argentina. (F. Urbano- PI/Bisagno – Co-PI) Understanding thalamcortical dynamics in psychostimulant exposed mice through combined patch clamp, voltage sensitive dye imaging and morphological techniques. 2009 – 2013, Total $Ars 299.100, USD$ 70.000.

ANPCyT, FONCYT PPL2011, 2-0008 EBAL, Argentina. (C. Carbone-PI/ Bisagno– Co-PI), Preclinical studies, Pharmacological Research Institute, CONICET, 2012 – 2015, Total $Ars 7.998.811.USD$ 1.777.500.

ANPCyT, FONCYT, PICT 2012-0924, Argentina. (Bisagno V. – PI/ Urbano F.- Co-PI) Efectos nocivos del consumo combinado de los estimulantes cocaína y cafeína en un modelo animal: alteraciones del sistema tálamocortical somatosensorial y su impacto sobre las transiciones sueño-vigilia. 2013 – 2016, Total $Ars 329.992, USD$ 50.000.

ANPCyT, FONCYT, PICT 2012-1769, Argentina. (Urbano F. – PI/Bisagno V. – Co-PI) Rol de la leptina y la grelina en la regulación de los ciclos sueño-vigilia. Caracterización de la modulación por leptina y grelina de las propiedades intrínsecas de las neuronas del tronco del encéfalo y reticular del tálamo de ratón. 2013 – 2016, Total $Ars 329.995, USD$ 50.000.

ANPCyT, FONCYT, PICT-E 2014-0202, Argentina. (Bisagno V. – PI). (2015). Actualización de equipos para la optimización de técnicas de investigación en farmacología. Total $Ars 850.000, USD$ 110.000.

ANPCyT, FONCYT, PICT 2014-2499, Argentina. (Gonzalez, B.- IR) Bisagno V.-Miembro Grupo Colaborador). Alteraciones Epigenéticas Derivadas del tratamiento con drogas estimulantes y su implicancia sobre el funcionamiento de la corteza prefrontal. Total $Ars 105.000. USD$ 7000

IBRO-PROLAB, 2016. IBRO-PROLAB Program. IIBCE, Uruguay/ININFA-Argentina PI: Dra. Maria Cecilia Scorza y Dra. Veronica Bisagno. Total: Euros 4000.

ANPCyT, FONCYT, PICT 2015-2594, Argentina. (Bisagno V. – IR). Efectos farmacológicos de estimulantes adictivos versus estimulantes pro-cognitivos: análisis de blancos diferenciales en la corteza prefrontal del ratón. Total $Ars 777.263. USD$ 50.000

COLLABORATIONS

Nationals

Dr. Francisco J. URBANO SUAREZ

Researcher, CONICET. IFIBYNE (UBA-CONICET). Professor, UBA.

Dr. Candela GONZALEZ

Researcher, CONICET, Universidad Maimonides.

Internationals

Dr. Maria Cecilia SCORZA

Staff Researcher, Instituto de Investigaciones Clemente Estable, Montevideo. República Oriental del Uruguay.

Dr. Jean-Lud CADET

Branch Chief, Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse (NIDA-NIH), Baltimore, Maryland, USA.

Dr Edgar Garcia-Rill

Director, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.